Mechanisms of non-Mendelian inheritance in genetic disease
نویسندگان
چکیده
منابع مشابه
Mechanisms of non-Mendelian inheritance in genetic disease.
Single gene disorders with Mendelian inheritance patterns have contributed greatly to the identification of genes and pathways implicated in genetic disease. In these cases, molecular analysis predicts disease status relatively directly. However, there are many abnormalities which show familial recurrence and have a clear genetic component, but do not show regular Mendelian segregation patterns...
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Evolution algebra theory is used to study non-Mendelian inheritance, particularly organelle heredity and population genetics of Phytophthora infectans. We can not only explain a puzzling feature of establishment of homoplasmy from heteroplasmic cell population and the coexistence of mitochondrial triplasmy, but also predict all mechanisms to form the homoplasmy of cell populations, which are hy...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2004
ISSN: 1460-2083
DOI: 10.1093/hmg/ddh254